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Plasma Zinc Level (AKU)

Specimen Required

Fasting Required

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Purpose of the Test

To measure the amount of zinc in the blood (or sometimes urine) in order to identify/diagnose deficiency or to monitor response to supplementation

When this test is required

When a person displays clinical symptoms that may be associated with zinc deficiency, or where there is a risk of developing deficiency, the measurement of zinc can determine if supplementation is required. Where supplementation is necessary the measurement of zinc can be used to assess when adequate concentrations are achieved.

What the Test Detects

This test measures the amount of zinc in the blood (or sometimes urine). Zinc is an essential trace element with important functions throughout the body. Zinc is important for protein synthesis, enzyme function and plays a structural role in proteins and nucleic acids. Zinc is a component of many high protein foods such as meat, fish and dairy products. It is present in vegetables and grains but the bioavailability is reduced…This test measures the amount of zinc in the blood (or sometimes urine). Zinc is an essential trace element with important functions throughout the body. Zinc is important for protein synthesis, enzyme function and plays a structural role in proteins and nucleic acids. Zinc is a component of many high protein foods such as meat, fish and dairy products. It is present in vegetables and grains but the bioavailability is reduced because dietary fibres can inhibit its absorption. Approximately 20-30% of ingested zinc is absorbed in the small intestine. Zinc is transported in the plasma bound to albumin (~80%) and a2-macroglobulin (~20%). The major route of zinc excretion is via the faeces with little being lost in urine, sweat and other bodily secretions. Zinc is present in many tissues throughout the body but is not stored at any particular site. Therefore in anabolic states where zinc requirements exceed intake, or where poor absorption occurs, zinc deficiency can result. Zinc deficiency can present clinically with hair loss, poor wound healing, dermatitis and impaired immune function. In children zinc deficiency can cause growth retardation. Conditions commonly associated with zinc deficiency include: alcoholism, pregnancy & burns. Acrodermatitis enteropathica is an inherited disorder of zinc metabolism/absorption. Zinc deficiency can be treated by supplementation and leads to improvement of clinical symptoms. See MoreSee Less

Preparation for the Test

Haemolysis (red blood cell rupture that occurs when the sample is taken) should be avoided as red blood cells contain ~10x the amount of zinc than that of plasma/serum. Fasting samples may be preferred as plasma/serum zinc concentrations have been shown to decrease after eating meals.

Sample Requirements

A blood sample is taken from a vein in the arm and/or a urine sample (preferably 24h collection) is provided.

Additional Notes

Medications such as steroids & oral contraceptives can reduce circulating concentrations of zinc. Pregnancy is associated with lower zinc concentrations due to increased circulating hormones in the body.Medications such as antibiotics and iron may compete with zinc for intestinal absorption.