It’s important to note that a TRUS-guided biopsy is not always accurate in detecting prostate cancer, and false negative results can occur. Additionally, the biopsy can sometimes miss cancer cells if they are located in an area that is not sampled. Patients should discuss the benefits and risks of TRUS-guided biopsy with their healthcare provider and weigh the potential benefits against the potential risks before undergoing the procedure. During the procedure, patients may experience discomfort or pain, and may also experience bleeding or discomfort afterwards. Patients should follow any post-procedure instructions given by their healthcare provider, including avoiding strenuous activity and taking any prescribed medications as directed. Patients may also need to undergo additional testing or follow-up appointments depending on the results of the biopsy.