Serum PIVKA – II Level

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

Purpose of the Serum PIVKA – II Level Test

The Serum PIVKA-II Level test is used to detect and monitor hepatocellular carcinoma (HCC), a type of liver cancer, in individuals with chronic liver disease.

When this Serum PIVKA – II Level test is required

The test may be requested as part of routine surveillance for HCC in individuals with chronic liver disease. It may also be ordered for individuals with a history of HCC to monitor for cancer recurrence.

What the Serum PIVKA – II Level Test Detects

The Serum PIVKA-II Level test measures the levels of a protein called protein induced by vitamin K absence or antagonist-II (PIVKA-II) in the blood. PIVKA-II is produced by liver cells and is elevated in individuals with HCC.

Preparation for the Serum PIVKA – II Level Test

No specific test preparation is needed, but you should inform your healthcare provider about any medications you are taking, including over-the-counter drugs and supplements.

Sample Requirements

The test requires a blood sample.

Additional Notes

HCC is a serious and potentially life-threatening condition. Early detection and treatment can improve outcomes. Regular surveillance is important for individuals with chronic liver disease. Elevated PIVKA-II levels may also be seen in other conditions, such as vitamin K deficiency or other types of cancer, so the test should be interpreted in the context of other clinical and laboratory findings.

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