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Serum CRP

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Test

May be used to predict your risk of developing heart disease

When this test is required

Unfortunately, there is no agreement about exactly when the test should be used, and who should have this test. There is not yet a consensus about its value, but the test is being promoted by some as a test to help cardiologists assess risk for acute coronary syndrome (clogged blood vessels around the heart). Some doctors use the test to assist with making the decision whether to prescribe lipid lowering medication to reduce vascular risk. Where the decision has already been made to commence lipid lowering treatment, there may be little to be gained by measuring hs-CRP.hs-CRP may be requested as one of several tests for a cardiovascular risk profile, often along with lipid (fat) tests, like the various tests for cholesterol and triglycerides. Some experts say that the best way to predict risk is to combine a good marker for inflammation, like CRP, along with the ratio of total cholesterol to HDL cholesterol.Currently there are no official guidelines on using hs-CRP as a test in screening for cardiovascular risk. Recent studies have shown, however, that the hs-CRP test may be useful in identifying risk in healthy individuals as well as in people who have symptoms of chest pain. This is not current UK practice.

What the Test Detects

C-reactive protein (CRP) is a protein in the blood that increases when inflammation is present. CRP has been used for many years as an indicator of infection and inflammation associated with disease. Doctors now believe that atherosclerosis (fatty build-up in artery walls, also called ‘hardening of the arteries’) is also an inflammatory process. However, the inflammation from atherosclerosis is a low level of long-term inflammation that produces only small amounts of CRP. Therefore, the test requires higher sensitivity than previous tests in order to detect the small increases of CRP. Thus, this test is known as high-sensitivity CRP or hs-CRP.How is the sample collected for testing?A blood sample is taken by needle from a vein in your arm.Is any test preparation needed to ensure the quality of the sample?No test preparation is needed.See MoreSee Less

Preparation for the Test

None required

Sample Requirements

A blood sample taken from a vein in your arm

Additional Notes

Currently, relatively few UK laboratories perform the hs-CRP blood test and not all laboratories have the ability to do it.Taking aspirin or pravastatin (a cholesterol-lowering drug) may reduce CRP levels in blood. Both aspirin and pravastatin may help to reduce the inflammation linked to the atherosclerotic process. Other drugs, such as nonsteroidal anti-inflammatory drugs (for example ibuprofen) and glucocorticoid drugs, may also lower the concentration of CRP in the bloodstream.Because hs-CRP tests measure a marker for inflammation, doctors need to know about recent medical events that may also have increased CRP levels, such as recent surgery, tissue injury, infections, or general inflammation, from conditions like arthritis.hs-CRP and CRP tests measure levels of the same molecule. The hs-CRP test is designed to measure lower levels of the molecule. People with inflammation, such as those with arthritis or infections should not have hs-CRP levels measured because their results cannot be considered in the context of heart disease. Their CRP levels would be very high—too high for hs-CRP to be measured meaningfully.