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Serum Chloride

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Serum Chloride Test

To determine if there is a problem with your body’s acid-alkali (pH) balance and to monitor treatment

When this Serum Chloride test is required

A blood chloride test may be requested to help evaluate kidney function and acid-base status. It may also be requested if you are in hospital and receiving intravenous (IV) fluids. If your sodium measurement is abnormal, the doctor may look at whether the chloride measurement changes in the same way. This may help the doctor to workout if there is also a problem with acid or base and may help guide treatment.

What the Serum Chloride Test Detects

Chloride is an electrolyte. When combined with sodium it is mostly found in nature as “salt.” Chloride is important in maintaining the normal acid-base balance of the body and, along with sodium, in keeping normal levels of water in the body. Chloride generally increases or decreases in direct relationship to sodium, but may change without any change in sodium when there are problems with too much acid or base in your body. Chloride is taken into the body through food. Most of the chloride is absorbed by the gastrointestinal tract, and the excess is excreted in urine. The normal blood concentration remains steady, with a slight drop after meals (because the stomach produces hydrochloric acid after eating, using chloride from blood).See MoreSee Less

Preparation for the Serum Chloride Test

None

Sample Requirements

A blood sample taken from a vein in the arm or a urine sample

Additional Notes

Drugs that affect sodium blood levels will also cause changes in chloride such as the use of diuretics. In addition, the chronic use of laxatives or taking more than the recommended dosage of antacids can also cause low blood chloride.