Caeruloplasmin may be increased in a variety of circumstances which need to be considered when using it to diagnose or monitor Wilson disease or copper deficiency. These circumstances may include: Caeruloplasmin levels increases when someone has inflammation, severe infection, tissue damage, and some cancers. Increases are also seen during pregnancy and with the use of oestrogen, oral contraceptives, and medications such as carbamazepine, phenobarbital, and valproic acid.Caeruloplasmin is not a routine test. Unless your doctor suspects that you have Wilson disease or a problem with your copper metabolism, it is unlikely that you will ever have this test performed.
