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Serum CA 125

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Test

To monitor treatment for ovarian cancer or to investigate for a possible ovarian cancer.

When this test is required

Before a patient starts treatment for ovarian cancer, the doctor will measure CA 125 to be able to compare it with future measurements. During therapy, doctors use CA 125 testing, at intervals, to follow the response to therapy. CA 125 may also be measured several times after therapy is completed to catch any early signs of the cancer’s return.CA 125 may also be requested by your GP if you have persistent or frequent symptoms (e.g. unexplained tummy pain, bloating, feeling full and/or loss of appetite or problems with urination) to determine if you require an ultrasound scan of the abdomen and pelvis.

What the Test Detects

CA 125 is a protein often found on the surface of ovarian cancer cells and in some normal tissues. It is used as a marker for ovarian cancer. However, CA 125 levels may also be high in other types of non-cancerous conditions, including menstruation, pregnancy, and pelvic inflammatory disease.See MoreSee Less

Preparation for the Test

None

Sample Requirements

A blood sample taken from a vein in the arm

Additional Notes

A CA 125 result that is higher than normal does not always mean a patient has ovarian cancer. CA 125 can be high in many normal or benign conditions (for example, pregnancy, menstruation, uterine fibroids, endometriosis and pelvic inflammatory disease). A CA 125 test isn’t accurate enough to use for ovarian cancer screening in the general population, because many noncancerous conditions (such as those described above) can increase the CA 125 result..