Before a patient starts treatment for ovarian cancer, the doctor will measure CA 125 to be able to compare it with future measurements. During therapy, doctors use CA 125 testing, at intervals, to follow the response to therapy. CA 125 may also be measured several times after therapy is completed to catch any early signs of the cancer’s return.CA 125 may also be requested by your GP if you have persistent or frequent symptoms (e.g. unexplained tummy pain, bloating, feeling full and/or loss of appetite or problems with urination) to determine if you require an ultrasound scan of the abdomen and pelvis.