Serum Anti-Tissue Transglutaminase IgA

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

Purpose of the Test

This test is used to help diagnose and monitor celiac disease, an autoimmune disorder in which the ingestion of gluten leads to damage in the small intestine.

When this test is required

This test may be requested if a person has symptoms of celiac disease, if they have a family history of the condition, or if they have other autoimmune disorders that may be associated with celiac disease

What the Test Detects

This test measures the level of IgA antibodies against tissue transglutaminase, an enzyme that is found in the small intestine. In people with celiac disease, the immune system mistakenly identifies gluten as a foreign invader and produces antibodies against it. These antibodies can also attack tissue transglutaminase, leading to damage in the small intestine.

Preparation for the Test

No special preparation is required for this test.

Sample Requirements

A blood sample is required for this test.

Additional Notes

It is important to continue consuming gluten-containing foods prior to testing for celiac disease. If a person has already started a gluten-free diet, this may affect the accuracy of the test results.

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