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Serum ALT (SGPT)

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Test

To screen for liver disease

When this test is required

A doctor usually requests an ALT test with other laboratory investigations to evaluate a patient who has symptoms of a liver disorder. ALT is used to identify liver damage. Some of these symptoms include jaundice, dark urine, nausea, vomiting, abdominal swelling, unusual weight gain and abdominal pain. ALT can also be used, either by itself or with other tests, for patients at risk of developing liver disease such as: persons who have a history of known or possible exposure to hepatitis viruses those who drink too much alcohol those whose family have a history of liver disease people who take drugs that might damage the liver those who are overweight or who have diabetesIn people with mild symptoms, such as tiredness or loss of energy, ALT may be tested to make sure they do not have chronic (long-term) liver disease. ALT is often used to monitor the treatment of persons who have liver disease to see if the treatment is working and may be requested either by itself or along with other blood tests.

What the Test Detects

ALT is an enzyme found mostly in the liver; smaller amounts are also found in the kidneys, heart and muscles. When the liver is damaged, ALT is released into the bloodstream, hence increasing the concentration that can be detected in a blood test. This often happens before more obvious symptoms of liver damage occur, such as jaundice (yellowing of the eyes and skin).See MoreSee Less

Preparation for the Test

No test preparation is needed, although you should inform your doctor about any drugs you are taking

Sample Requirements

A blood sample will be taken from a vein in the arm

Additional Notes

An injection of medicine into the muscle tissue or strenuous exercise may increase ALT concentration as it is released into the bloodstream from muscle.Certain drugs may cause liver damage, resulting in high ALT concentrations. This occurs in a very small percentage of patients and is true of both prescription drugs and some ‘natural’ health products. If your doctor finds that you have a high ALT, tell them about all the drugs and health products you are taking.