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Liver Function Test With GGT

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Test

To screen for and monitor liver disease

When this test is required

These tests are used when symptoms suspicious of a liver condition are noticed. These include: jaundice, dark urine and light-coloured stools; nausea, vomiting and diarrhoea; loss of appetite; vomiting of blood; bloody or black stools; swelling or pain in the belly; unusual weight change; and fatigue or loss of stamina. One or more of these tests may be requested when a person has been or may have been exposed to a hepatitis virus; has a family history of liver disease; has excessive alcohol intake; or is taking a drug that can cause liver damage.

What the Test Detects

The liver is a large organ located in the upper right-hand part of the abdomen behind the lower ribs. It takes up drugs and toxic substances from the blood and renders them harmless. It produces proteins, including enzymes and blood clotting factors, helps maintain hormone balance and stores vitamins. The liver produces bile, a fluid that is transported through ducts to the gallbladder to be stored and then to the small intestine…The liver is a large organ located in the upper right-hand part of the abdomen behind the lower ribs. It takes up drugs and toxic substances from the blood and renders them harmless. It produces proteins, including enzymes and blood clotting factors, helps maintain hormone balance and stores vitamins. The liver produces bile, a fluid that is transported through ducts to the gallbladder to be stored and then to the small intestine to help digest fats.Liver disease can be detected, evaluated and monitored by combinations of up to five tests measured at the same time on a blood sample. These may include:Alanine aminotransferase (ALT) – an enzyme mainly found in the liver; the best test for detecting hepatitis Aspartate aminotransferase (AST) – an enzyme found in the liver and a few other places, particularly the heart and other muscles in the body Total bilirubin – measures all the yellow bilirubin pigment in the blood Conjugated bilirubin, measures the form made only in the liver and is often requested with total bilirubin in infants with jaundice Alkaline phosphatase (ALP) – an enzyme related to the bile ducts; often increased when they are blocked, either inside or outside the liver Albumin – measures the main protein made by the liver and tells how well the liver is making this protein Total protein – measures albumin and all other proteins in blood, including antibodies made to help fight off infections Other tests that can help to assess the liver include gamma-glutamyl transferase (GGT), prothrombin time (PT), P3NP, ELF and sometimes urine testing. See MoreSee Less

Preparation for the Test

None

Sample Requirements

A blood sample taken from a vein in your arm

Additional Notes

Depending on the history, examination and results of the liver blood tests your doctor may request one or more further tests including hepatitis virus antibodies A, B and C, alpha-fetoprotein (AFP), alpha-1 antitrypsin (mostly for children), copper, caeruloplasmin, iron and transferrin and smooth muscle antibody. Sometimes imaging scans are requested.