HLA Class I Tissue Typing for Patient

Specimen Required

Fasting Required

Purpose of the Test

HLA tissue typing is performed to determine the genetic makeup of human leukocyte antigen (HLA) molecules present on the surface of cells. This information is used to identify the best match between a donor and a recipient for organ transplantation, to diagnose certain autoimmune diseases, and to determine the risk of developing certain diseases.

When this test is required

HLA tissue typing is typically requested when a person is being considered for organ transplantation or if a person has symptoms suggestive of an autoimmune disease.

What the Test Detects

HLA tissue typing tests the DNA sequence of the HLA genes, which encode proteins that are essential for the immune system to recognize and respond to foreign invaders, such as viruses and bacteria. There are two main classes of HLA molecules, class I and class II, and each class has multiple subtypes. The HLA tissue typing test typically focuses on the class I HLA genes, which are present on almost all nucleated cells in the body.

Preparation for the Test

No specific test preparation is required for HLA tissue typing.

Sample Requirements

The sample required for HLA tissue typing is typically a blood sample, which is collected from a vein in the arm.

Additional Notes

HLA tissue typing is a complex test that requires specialized equipment and expertise to perform and interpret. The results of the test are reported as a series of numbers and letters that represent the specific HLA alleles present in the individual being tested. These results are used to determine the compatibility between a donor and recipient for organ transplantation.

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