Growth Hormone Suppression Test (with Glucose Challenge)

Specimen Required

Fasting Required

Purpose of the Growth Hormone Suppression Test (with Glucose Challenge) Test

The Growth Hormone Suppression Test (with Glucose Challenge) is used to diagnose growth hormone disorders such as acromegaly and gigantism. It is also used to monitor the effectiveness of treatment for these conditions.

When this Growth Hormone Suppression Test (with Glucose Challenge) test is required

The test is typically requested by an endocrinologist or other healthcare provider when an individual has symptoms of acromegaly or gigantism, such as increased growth rate, enlarged hands or feet, or changes in facial features. The test may also be ordered to monitor the effectiveness of treatment for these conditions.

What the Growth Hormone Suppression Test (with Glucose Challenge) Test Detects

The Growth Hormone Suppression Test (with Glucose Challenge) measures the levels of growth hormone in the blood before and after administering a glucose solution. Glucose is a sugar that stimulates the release of insulin, which in turn should suppress the release of growth hormone.

Preparation for the Growth Hormone Suppression Test (with Glucose Challenge) Test

Prior to the test, the individual will be asked to fast for at least 10-12 hours. Certain medications, including some oral contraceptives and glucocorticoids, may need to be discontinued for several days before the test. The healthcare provider will provide specific instructions on how to prepare for the test.

Sample Requirements

The test requires several blood samples to be taken over a period of several hours.

Additional Notes

The Growth Hormone Suppression Test (with Glucose Challenge) is considered safe, but there is a small risk of low blood sugar (hypoglycemia) in individuals who have impaired glucose tolerance or who are taking certain medications. The healthcare provider will monitor the individual’s blood sugar levels throughout the test to ensure that they remain within a safe range.

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