The test may be ordered if a person has symptoms of a thyroid disorder, such as weight changes, fatigue, heat or cold intolerance, irregular heart rate, and hair loss. It may also be ordered if a person has an enlarged thyroid gland (goiter), a family history of thyroid disease, or if they have been diagnosed with an autoimmune disorder such as Hashimoto’s thyroiditis or Graves’ disease.
The extended thyroid profile test measures the levels of various hormones in the thyroid gland, including free T3, free T4, total T3, total T4, and TSH. Free T3 and T4 are hormones that are not bound to proteins and are available to be used by the body’s cells. Total T3 and T4 measure both the free hormone levels and the levels of hormones that are bound to proteins. TSH is a hormone that stimulates the thyroid gland to produce T3 and T4.