The Cross Matching with donor Screening test is used to ensure compatibility between the blood of a patient and a specific donor before a blood transfusion is performed. The test checks for the presence of antibodies in the recipient’s blood that may react with antigens on the donor’s blood cells. The donor screening component of the test checks for the presence of infectious agents such as HBsAg, HCV, HIV, HBc, VDRL, and MP.