COOMB’s Direct (Polyspecific & Monospecific)

Specimen Required

3cc EDTA BLOOD (CBC VIAL)

Fasting Required

Purpose of the Test

The Coombs Direct (Polyspecific) test is performed to detect the presence of antibodies against red blood cells. It is used to diagnose and monitor autoimmune hemolytic anemia and to investigate transfusion reactions.

When this test is required

The test may be ordered if a patient has symptoms of autoimmune hemolytic anemia or if they have had a transfusion reaction.

What the Test Detects

The Coombs Direct (Polyspecific) test detects the presence of antibodies against red blood cells in the blood. The antibodies can be produced by the body’s immune system in response to certain conditions, such as autoimmune hemolytic anemia or transfusion reactions.

Preparation for the Test

There is no specific preparation required for the Coombs Direct (Polyspecific) test.

Sample Requirements

A blood sample is required for the test, which is typically taken from a vein in the arm.

Additional Notes

The Coombs Direct (Polyspecific) test is just one of several tests that may be used to diagnose autoimmune hemolytic anemia and investigate transfusion reactions. Other tests may include the Coombs Indirect test or a complete blood count. It is important to follow the healthcare provider’s instructions regarding testing and treatment.

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