cMPL Mutation (W515k,W515L) (From NIBD)

Specimen Required

10cc EDTA Whole Blood

Fasting Required

Purpose of the Test

The cMPL mutation test is a genetic test used to identify specific mutations in the cMPL gene that are associated with a type of blood cancer called primary myelofibrosis (PMF). The two mutations tested for are W515k and W515L.

When this test is required

The cMPL mutation test may be requested by a hematologist or other healthcare provider who suspects a patient may have PMF.

What the Test Detects

The cMPL mutation test detects specific mutations in the cMPL gene, which plays a role in regulating blood cell production. These mutations are associated with the development of PMF.

Preparation for the Test

No specific test preparation is required for cMPL mutation testing.

Sample Requirements

The sample required for the test is usually a blood sample or bone marrow sample.

Additional Notes

It is important to note that the cMPL mutation test is just one tool used in the diagnosis and management of PMF, and results should be interpreted in conjunction with other clinical and laboratory findings. Counseling may be recommended for individuals who test positive for the mutation, as they may have an increased risk of developing PMF or passing the mutation on to their children.

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