Chimerism Donor (Form NIBD)

Specimen Required

4 Buccal Swab of Patient Right & Left, 3cc EDTA Patient & Donor

Fasting Required

Purpose of the Test

If a person has undergone a bone marrow or stem cell transplant, chimerism testing can help determine whether the transplant was successful in terms of replacing the recipient’s cells with donor cells. If a significant number of the recipient’s cells remain, the transplant may not have been successful, or there may be complications that need to be addressed.

When this test is required

Chimerism testing is typically requested after a bone marrow or stem cell transplant to monitor the success of the transplant and to detect any potential complications. The test may also be requested in some cases to monitor the progression of certain types of cancer or other conditions where chimerism is a factor. The test involves analyzing the DNA of the donor and recipient cells in a sample of blood or bone marrow. The results of the test can indicate the percentage of donor cells present in the sample and help doctors determine whether the transplant has been successful.

What the Test Detects

Chimerism testing is used to determine the proportion of donor and recipient cells in a person’s body after a bone marrow or stem cell transplant. This type of test is used to monitor the success of the transplant and to detect any complications that may arise.

Preparation for the Test

There is usually no specific preparation required for chimerism testing, although you should inform your doctor of any medications or supplements you are taking, as these may affect the results. It is also important to let your healthcare provider know if you have any bleeding disorders or are taking blood-thinning medications, as this may affect the collection of a blood sample.

Sample Requirements

The test requires a blood or bone marrow sample, depending on the type of transplant or treatment being monitored. The sample will be collected by a healthcare professional using a needle, and the procedure is usually quick and straightforward.

Additional Notes

It is important to note that chimerism testing is not a routine test and is typically only used in specific medical situations, such as after a bone marrow or stem cell transplant. Your doctor will be able to advise you on whether this type of test is necessary for your individual medical situation. It is also important to follow any instructions from your healthcare provider regarding the timing of the test and the sample collection process. You may need to refrain from eating or drinking for a period of time before the test or stop taking certain medications that could affect the results. Your healthcare provider will provide specific instructions on how to prepare for the test.

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