Bone Marrow for Fungus Stain/Fungal Smear (KOH)

Specimen Required

Bone

Fasting Required

Purpose of the Test

Bone marrow testing for fungus stain using KOH preparation is ordered when there is a suspicion of a fungal infection in the bone marrow. Fungal infections of the bone marrow are rare but can occur in people with weakened immune systems or in those who have undergone bone marrow transplantation.

When this test is required

A healthcare provider may request a bone marrow test for fungus stain using KOH preparation if a person has symptoms of a fungal infection, such as fever, chills, sweats, and fatigue, and has risk factors for fungal infections, such as a weakened immune system. Bone marrow testing for fungus stain may also be performed if other diagnostic tests, such as blood tests, imaging tests, or biopsy, are inconclusive.

What the Test Detects

The bone marrow test for fungus stain using KOH preparation is used to detect the presence of fungal organisms in a bone marrow sample. This test involves treating the bone marrow sample with potassium hydroxide (KOH) solution, which dissolves any non-fungal material and makes it easier to see the fungal organisms under a microscope.

Preparation for the Test

There is no specific test preparation required for bone marrow testing for fungus stain using KOH preparation. However, a healthcare provider may give instructions to the person undergoing the test, such as fasting or avoiding certain medications or supplements, depending on their individual situation.

Sample Requirements

To perform a bone marrow test for fungus stain using KOH preparation, a healthcare provider will collect a bone marrow sample using a needle inserted into the bone marrow space. The sample is then treated with potassium hydroxide (KOH) solution to dissolve any non-fungal material and make it easier to see the fungal organisms under a microscope. The healthcare provider will then examine the bone marrow sample under a microscope to look for the presence of fungal organisms.

Additional Notes

The bone marrow test for fungus stain using KOH preparation is a minimally invasive procedure that involves inserting a needle into the bone marrow space to collect a sample. The sample is then treated with KOH solution and examined under a microscope by a healthcare provider with expertise in fungal infections. While the test can help diagnose fungal infections of the bone marrow, it is important to note that other diagnostic tests may also be needed, such as blood cultures or PCR testing, to confirm the diagnosis and guide treatment.

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