This is a medical procedure, not a test, so the reasons for getting a biopsy with H/P (histopathology) depend on the specific medical condition and symptoms of the patient. In general, a biopsy with H/P is a procedure in which a small sample of tissue is removed from a person’s body to be examined under a microscope. The H/P part refers to the process of preparing the tissue sample and staining it so that it can be viewed under a microscope by a pathologist.