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Antinuclear Antibodies (ANA)

Specimen Required

3-5cc Clotted Blood or Serum

Fasting Required

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Purpose of the Test

To help diagnose systemic lupus erythematosus (SLE) (commonly called lupus), drug induced SLE-like syndrome, Sjogren’s syndrome, scleroderma and certain other autoimmune connective tissue diseases

When this test is required

Autoimmune diseases can present in different ways. Symptoms (such as painful or swollen joints, unexplained fever, extreme tiredness, a red rash) may come and go over time and may be mild or severe. They could be due to a wide range of causes, and it may take months or years for these symptoms to show a pattern that might suggest SLE or any of the other autoimmune diseases. ANA offers a reliable first step or screening test for identifying SLE and some other autoimmune disorders.

What the Test Detects

Preparation for the Test

None needed; however, some drugs interfere with the test, so tell your doctor about any medications you are taking.

Sample Requirements

A blood sample taken from a vein in your arm

Additional Notes

Some drugs and infections as well as other conditions can give a false positive result for the ANA test. Some (but not all) of these drugs may bring on a condition that includes SLE symptoms, called drug-induced SLE-like syndrome. When the drugs are stopped, the symptoms usually go away. Although many medications have been reported to cause drug-induced lupus, those most closely associated with this syndrome include hydralazine, isoniazid, procainamide, and several anticonvulsants.