The test may be requested if a person has symptoms of tuberculosis that may affect the heart, such as chest pain, shortness of breath, and fatigue. The test may also be requested if other tests, such as imaging studies or a tuberculin skin test, suggest that tuberculosis may be present in the pericardium. The AFB C/S test may be ordered along with other tests, such as a biopsy or imaging studies, to help confirm a diagnosis of cardiac tuberculosis.