Alcohol intoxication can be harmful for a variety of reasons, including:

• Impaired brain function resulting in poor judgment, reduced reaction time, loss of balance and motor skills, or slurred speech.
• Dilation of blood vessels, causing a feeling of warmth but resulting in rapid loss of body heat.
• Increased risk of certain cancers, stroke, and liver diseases (e.g., cirrhosis), particularly when excessive amounts of alcohol are consumed over extended periods of time.
• Damage to a developing fetus if consumed by pregnant women.
• Increased risk of motor-vehicle traffic crashes, violence, and other injuries.

Coma and death can occur if alcohol is consumed rapidly and in large amounts.